Xeomin (incobotulinumtoxinA) is an FDA-approved botulinum toxin type A that relaxes expression muscles to soften frown lines. It is often called the 'naked' toxin because it contains no complexing proteins — only the active molecule — and its dosing is close to 1:1 with Botox.
Clinically, Xeomin behaves much like Botox. The formulation difference matters most to patients who have been treated for years, since complexing proteins are one theoretical route to developing resistance to a toxin over time.
Founder & Board-Certified Family Nurse Practitioner
Founder of BUTEX Medical Spa in Frisco, Texas, and a board-certified Family Nurse Practitioner who has been treating patients across North Texas since 2012. She performs every assessment and treatment personally.
Last reviewed
Appointment time
10–20 minutes
Downtime
None
Results appear
3–5 days, full effect at 10–14 days
How long it lasts
3–4 months
Sessions needed
Repeated as the effect wears off
The process
How Xeomin works
01
Review of your treatment history
Xeomin is a common choice for patients who feel their usual product has stopped lasting as long, and for anyone who prefers a formulation without added proteins.
02
Mapping and dosing
Units are close to 1:1 with Botox, so if you know your usual Botox dose it translates fairly directly.
03
Injection and aftercare
Identical to any neuromodulator: upright for four hours, no strenuous exercise for 24 hours, no rubbing the treated area.
Is Xeomin right for you?
You want a botulinum toxin without complexing proteins
You feel your current product is not lasting as long as it once did
You are treating frown lines, forehead lines or crow's feet
You are not pregnant, breastfeeding, or affected by a neuromuscular disorder
Benefits
No complexing proteins — the purified active molecule only
Dosing translates closely from Botox, making a switch straightforward
Same onset and duration as the other toxins
Stable at room temperature before reconstitution, so it is reliably fresh
Botox vs Dysport vs Xeomin vs Letybo
All four are botulinum toxin type A. They differ in formulation, dosing units and how quickly they take effect — not in whether they work.
Botox
Dysport
Xeomin
Letybo
Active
OnabotulinumtoxinA
AbobotulinumtoxinA
IncobotulinumtoxinA
LetibotulinumtoxinA
Typically visible
3–5 days
2–3 days
3–5 days
3–5 days
Full effect
10–14 days
10–14 days
10–14 days
10–14 days
Usually lasts
3–4 months
3–4 months
3–4 months
3–4 months
Units are interchangeable
No
No — roughly 2.5–3 units per 1 Botox unit
No — close to 1:1 with Botox
No
Complexing proteins
Yes
Yes
None — a purified toxin
Yes
Common questions
Xeomin questions, answered
Is Xeomin better than Botox?
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Neither is better — they are comparable in onset, duration and effect. Xeomin's distinction is that it contains no complexing proteins, which is why it is often chosen by long-term toxin patients.
Can I switch from Botox to Xeomin?
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Yes, and the dosing is close to 1:1, so your usual unit count is a good starting point. We still reassess at two weeks after a switch.
How long does Xeomin last?
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Typically 3–4 months, the same range as Botox and Dysport. Duration varies with dose, muscle strength and metabolism.
Why is it called the naked toxin?
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Because the accessory proteins that surround the active molecule in other formulations have been removed. Only the botulinum toxin type A itself is present.
This page is general information, not medical advice, and it does not replace an in-person assessment. Results vary between patients, and no outcome is guaranteed. Suitability, risks and alternatives for xeomin are discussed at consultation. Call (469) 432-0868 to book.
Book a consultation
Ask us about Xeomin
A consultation covers whether xeomin suits you, what it will cost, and what it realistically will and will not do. No obligation to book treatment on the day.
